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ORIGINAL ARTICLE
Year : 2022  |  Volume : 12  |  Issue : 1  |  Page : 21-27

Evaluation of the effects of the extract of dried roots of Jatropha curcas in the female Wistar rats


1 Department of Medicine, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria
2 Department of Biochemistry, College of Medicine, University of Lagos State, Idi-Araba, Lagos, Nigeria

Correspondence Address:
Dr. Ayotunde O Ale
Department of Medicine, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu Campus, Ogun State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajem.ajem_10_22

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Background: Jatropha curcas is a multipurpose plant with medicinal properties along with the capability to produce cheap, commercially lucrative biofuel. Literature search reveals well-known medicinal uses of different parts of J. curcas, especially in traditional medicine; also, some studies have established the medicinal role of different parts of the plant in in-vitro and in-vivo models. Objectives: The objective is to evaluate the effects of oral administration of ethanolic and aqueous extracts of dried roots of J. curcas on the liver function in adult female rats. Materials and Methods: Rats were procured from the Animal House of the University of Ibadan. They were allowed a period of acclimatization (for 15 days) and divided into five groups (n = 4): four groups (groups A to C) were treated with aqueous extracts of dried roots of J. curcas, one group (group D) was treated with ethanolic extract of the same, and Group E did not receive any treatment (control group). After oral administration of the preparation for 15 days, the rats were sacrificed under anesthesia and blood samples were sent for biochemical analysis. Measurement of liver enzymes such as serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), albumin, total protein, bilirubin, and urea levels was carried out. Results: SGOT, SGPT, and urea levels were significantly lower in the alcoholic extract-treated group (group D) when compared with other aqueous extract-treated groups; also the total protein level was significantly lower in the rats in group D. ALP and bilirubin levels were significantly lower in some of the aqueous extract-treated groups (groups A and C, respectively). Conclusion: None of the extracts (aqueous and ethanolic) was found to be totally safe in adult female rats with regard to liver function. However, further study is required with larger sample size with prolonged period of administration and measurement of other biochemical and hematological parameters.


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