| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 12
| Issue : 1 | Page : 15-20 |
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Vitamin D status and bone health in healthy adult Nigerians
Ayotunde Oladunni Ale1, Sanya Bamidele Osalusi1, Olusola L Adeyemo2
1 Department of Medicine, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
2 Obafemi Awolowo College of Health Science, Olabisi Onabanjo University, Agoiwoye, Ogun State, Nigeria
Correspondence Address:
Dr. Ayotunde Oladunni Ale
Department of Medicine, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State
Nigeria
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/ajem.ajem_7_21
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Background: With the emergence of osteoporosis as a major public health concern among economically developed nations, more research is needed on the prevalence and etiology of this and related diseases in resource-limited countries. This study evaluated vitamin D status and its relationship with skeletal health in healthy adult Nigerians. Materials and Methods: Forty apparently healthy subjects between the ages of 21 and 50 were recruited in this prospective study. A variety of physiological parameters were assessed including markers of bone health, thyroid function, and renal function, as well as parathyroid hormone levels, calcium excretion rates, and serum 25-hydroxyvitamin-D levels. Bone mineral density (BMD) was evaluated via dual-energy X-ray absorptiometry. Results: Mean serum 25-hydroxyvitamin-D level was 53 (15.66) nmol/L and 70% of the subjects had vitamin D insufficiency. Osteopenia was observed in 25% of the subjects, and none of the subjects presented with osteoporosis. The BMD T-score of subjects with osteopenia was significantly lower when compared with non-osteopenic subjects. Serum osteocalcin was significantly higher in osteopenic subjects when compared with non-osteopenic subjects, but 24-h calcium excretion was comparable between the two groups. Mean serum 25-hydroxyvitamin-D in subjects with osteopenia was lower when compared with non-osteopenic subjects, whereas thyroid, renal, and calcium-phosphorus parameters were not significantly different between the groups. Conclusion: There is a high rate of vitamin D insufficiency and bone loss among apparently healthy Nigerians, and we propose vitamin D status and bone health as targets for intervention. |
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